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乳がんの脳転移メカニズムにエクソソームが関与 脳転移の早期診断への応用に期待

2015年4月2日
国立研究開発法人 国立がん研究センター

本研究成果のポイント
乳がん細胞の脳転移メカニズムにエクソソームと特定のマイクロRNAが関与していることを世界に先駆け報告。

  • 乳がん細胞より分泌されるエクソソームという小胞による新たな脳転移メカニズムを解明した。
  • エクソソームに含まれるマイクロRNA(miR-181c)が血液脳関門を破壊することで脳転移に関与していることを明らかにした。
  • 脳転移患者血清においても、miR-181cの存在量が有意に上昇しており、早期診断・新規治療法の開発への応用に期待される。

<原文/ www.ncc.go.jp/jp/information/press_release

Translation:

Exosomes are Involved in the Brain Metastasis Mechanism of Breast Cancer

Expectations for Application in Early Diagnosis of Brain Metastasis

02 April 2015
National Cancer Center (National Research and Development Corporation)

Main Points from the Results of this Research
This is the first announcement to the world that a exosomes and a specific microRNA are involved in the brain metastasis of breast cancer cells.

  • Light has been shed on a new brain metastasis mechanism which is due to vesicles called exosomes that are secreted from cancer cells.
  • It has been made clear that microRNA (miR-181c) which is contained in the exosomes is involved in brain metastasis by destroying the blood-brain barrier.
  • There is a significant rise in the amount of miR-181c which exists in the serum of brain metastasis patients, and it is expected that this discovery will have applications in the development of methods for early diagnosis and new treatment methods.

エクソソーム exosome
脳転移 brain metastasis
小胞 vesicle, follicle
血液脳関門 けつえきのうかんもん blood-brain barrier

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ネット上のもともとの発表を見つけましたので、提供します。

「2015/05/07 緑茶と死亡・死因別死亡、コーヒーと死亡・死因別死亡について」

「多目的コホート(JPHC)研究から、緑茶摂取と全死亡リスクおよびがん、心疾患、脳血管疾患、呼吸器疾患及び外因死を含む5大死因死亡リスクとの関連を検討した研究の結果が発表されました。この研究により、緑茶を習慣的に摂取する群において、男女の全死亡リスク及び心疾患、男性の脳血管疾患及び呼吸器疾患による死亡リスクの減少が示されました。」

「この論文の状況は“Annals of Epidemiology 2015年 WEB先行公開中”: のとおりです。」

<原文/ epi.ncc.go.jp/jphc/745/3533.html

Translation:

May 7, 2015 — Green Tea and Death/Cause-Specific Mortality, Coffee and Death/Cause-Specific Death

The results of research was announced from the Multi-Purpose Cohort (JPHC) study that investigated the relationship between green tea intake and risk for total mortality as well as the five major causes of death including cancer, heart disease, cerebrovascular disease, respiratory tract disease and death by physical trauma. According to this research, a decrease in risk for total mortality and heart disease for men and women was shown in the group that habitually consumed green tea, as well a decrease in the risk of death for men due to cerebrovascular disease and respiratory tract disease.

The status of this paper is as disclosed on the internet in the Annals of Epidemiology 2015. [translator: see PubMed link below].

Source (Japanese): http://epi.ncc.go.jp/jphc/745/3533.html

——-

English Abstract on PubMed: www.ncbi.nlm.nih.gov/pubmed/25900254

——-

死因別死亡 cause-specific mortality
全死亡のリスク risk for total mortality
呼吸器疾患 respiratory tract disease
脳血管疾患 cerebrovascular disease; CVD
外因死 death by physical trauma
習慣的に habitually
摂取する consume, partake

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コーヒーで病死の危険減 1日3~4杯

「緑茶やコーヒーを毎日多く飲むと、心臓病や脳卒中などで死亡するリスクを低下させるとの調査結果を、東京大や国立がん研究センターなどの研究チームが発表した。」

<原文/ www.yomiuri.co.jp/science/

Translation: When you drink a lot of green tea or coffee every day, you reduce your risk of dying from heart disease or stroke, according to the results of an investigation announced today by a team of researchers from Tokyo University and the National Cancer Center.

「コーヒーを1日3~4杯飲む人は、ほとんど飲まない人に比べて心臓や脳血管、呼吸器の病気で死亡する危険性が4割ほど減るとの研究結果を、国立がん研究センターや東京大などの研究チームが7日、公表した。」

Translation: Those who drink from 3 to 4 cups of coffee per day have an almost 40% lower risk of dying from diseases of the heart, cerebral blood vessels, or respiratory organs, compared to those who drink almost no coffee, according to the results of research announced on May 7th by a research team from the National Cancer Center and Tokyo University.

「がんによる死亡との関連は見られず、全ての死亡の危険性で比較すると24%減だった… 1990年代に10都府県に住んでいた40~69歳の約9万人を2011年まで追跡し、生活習慣と日本人の主要な死因との関係を調べた。」

Translation: A correlation with death due to cancer was not seen, but the risk of death from all causes dropped by 24%… Beginning in the 1990s, about 90,000 people aged 40-69 living in 10 prefectures were followed to study the relationship between lifestyle and the principal causes of death among Japanese.

<原文/ www.47news.jp

-h2. フィールターも抗コレを

Coffee filters combat cholesterol-

脳卒中 a stroke, cerebral apoplexy
立がん研究センター National Cancer Center http://www.ncc.go.jp/en/about/index.html
脳血管 cerebral blood vessel
呼吸器 respiratory organs

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Keyword: Shouhisha Jikka Shisuu 消費者物価指数 Consumer Price Index

National Consumer Price Index for March

「全国 平成27年(2015年)3月分 前年同月比
総合:2.3%  生鮮食品を除く総合:2.2%  食料(酒類を除く)及びエネルギーを除く総合:2.1%」

National, March 2015, Compared to the Same Month Last Year
Overall: 2.3%; Overall excluding perishable foodstuffs: 2.2%; Overall excluding foodstuffs (excluding alcoholic drinks) and energy: 2.1%

Source: www.stat.go.jp/data/cpi/

「消費者物価指数 22か月連続で上昇」

The Consumer Price Index has risen for 22 consecutive months

Source: www3.nhk.or.jp/news

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Keyword: Toudouheki 凍土壁

「東京電力福島第一原子力発電所の汚染水対策の柱として建設が進められてきた『凍土壁』について、国と東京電力は、30日正午から、試験的に地盤を凍らせる作業を始めました。」

Regarding the “frozen ground wall” for which construction has been put forward as a pillar of countermeasures against contaminated water from Fukushima Daiichi Power Plant of Tokyo Electric, the Japanese government and Tokyo Electric Power Company have begun work to experimentally freeze the ground.

「福島第一原発で増え続ける汚染水の対策として、国と東京電力は、1号機から4号機までの周囲の地盤を凍らせ、全長1.5キロの氷の壁、「凍土壁」で取り囲み、建屋に流れ込む地下水を遮断する計画です。」

As a countermeasure against contaminated water at the Fukushima Daiichi Power Plant that continues to increase, the Japanese government and Tokyo Electric Power Company are planning to freeze the ground around reactors No. 1 through 4, tackle the problem with a wall of ice 1.5 km in length, and intercept underground water flowing into the building.

原文/Source: http://www3.nhk.or.jp/news/html/20150430/k10010065881000.html

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